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52-42)33-17-18-40(48
13-3)28(9)49-33
inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM
UNC0638 was used at 0
Nutlin-3, (4R5S, and 4S5R) Size:2mg solid 52-42)33-17-18-40(48Nutlin 3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin 3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Product information CAS Number: 548472 68 0 Molecular Weight: 581. 49 Formula: C30H30Cl2N4O4 Synonym: () Nutlin 3 Nutlin 3 Related CAS Number: