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InChi: InChI=1S/C32H53N2O4/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23
4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor for SIK1
InChiKey: PJDFLNIOAUIZSL-UHFFFAOYSA-N
AST 487 - CAS# 630124-46-8 Size:Solid 2 mg InChi: InChI=1S/C32H53N2O4/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23AST487, also known as NVP AST487, is a RET kinase inhibitor FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP AST487 has an IC(50) of 0. 88 mumol L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET
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