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Formula: C21H20N2O3S
based on pharmacokinetic experiments
In cultured primary neurons
Cocktail Formulation: 3 mM CHIR99021 and 2 mM SB431542 in DMSO solution Effective Concentration in Cell Culture: 3 µM CHIR99021 and 2 µM SB431542 in cell culture medium
ABT-888 dihydrochloride - CAS# 912445-05-7 0109 Formula: C21H20N2O3SABT 888 dihydrochloride, also known asVeliparib, CAS No. 912445 05 7, is a potent and selective Poly (ADP Ribose) Polymerase (PARP) Inhibitor. ABT 888 dihydrochloride enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation. ABT 888 dihydrochloride is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5. 2 and 2. 9 nM, respectively). Product information CAS Number: 912445 05 7