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InChi: InChI=1S/C24H23Cl3N4O/c25-16-7-9-18-15(13-16)5-4-6-19-22(24(32)29-30-11-2-1-3-12-30)28-31(23(18)19)21-10-8-17(26)14-20(21)27/h7-10
and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C
the less active isomer of (Z)-4-hydroxytamoxifen
and 10 μM) reduces cell viability in a concentration-dependent manner
AZD-5597 Catalog No.:M22668-C InChi: InChI=1S/C24H23Cl3N4O/c25-16-7-9-18-15(13-16)5-4-6-19-22(24(32)29-30-11-2-1-3-12-30)28-31(23(18)19)21-10-8-17(26)14-20(21)27/h7-10AZD 5597 is a potent CDK inhibitor with IC50 values of 2 nM for CDK1 and CDK2, respectively . The cyclin dependent kinases (CDKs) are serine threonine protein kinases with roles in the regulation of the cell cycle, and also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells . AZD 5597 is a potent imidazole pyrimidine amide CDK inhibitor. In LoVo cells, AZD 5597 exhibited high level of anti proliferative