CHMFL-ABL-053 21061 Chemical Name: 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1

Chemical Name: 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1

with an IC50 of <3 nM for DNA-PK

Smiles: CN(C)NC(=O)CCC(O)=O

Smiles: O=C(C1=CC=CC(F)=C1C1N=CC=CN=1)N1[C@H]2CC[C@@H]1C[C@H]2NC1=CN=C(C=N1)C(F)(F)F

CHMFL-ABL-053 21061 Chemical Name: 7-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1CHMFL ABL 053 (compound 18a) is a BCR ABL inhibitor with ABL1: IC50 of 70 nM. CHMFL ABL 053 is derived from a dihydropyrimidopyrimidine core scaffold based compound 27 (GNF 7). CHMFL ABL 053 inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM) and MEG 01 (GI50 = 16 nM), through significant suppression of the BCR ABL auto phosphorylation (EC50 = 100 nM) and downstream mediators such as STAT5, Crkl and ERK's