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PubMed PMID: 19338769
MD-224 (30 nM
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
Epub 2019 Jul 2
PD173955 - CAS# 260415-63-2 Catalog No.:M11371-2 PubMed PMID: 19338769PD 173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr Abl dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1 2 nM in kinase inhibition assays of Bcr Abl, and in cellular growth assays it inhibits Bcr Abl dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand dependent c kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand dependent proliferation of M07e
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